孙雪松（教授）的个人简介
孙雪松： 女,黑龙江,民族：汉,党派：共产党,博士，暨南大学研究员，博士研究生导师。
基本内容
孙雪松： 女,黑龙江,民族：汉,党派：共产党,博士，暨南大学研究员，博士研究生导师。从攻读博士开始至今一直致力于生物无机化学及功能蛋白组学的研究，着眼于细菌的金属离子代谢、毒力及耐药机制的研究。在该领域的研究结果已经在国际一流刊物上发表SCI论文30余篇，其中第一作者及通讯作者24篇，单篇最高引用率达150次，总引用率600次，H因子：10。应邀为Expert Rev. Proteomics, Metallomics，Curr. Drug. Metab. J Proteomics等期刊撰写本研究领域的综述性文章。研究结果得到同行专家的高度评价。发表在Metallomics上的文章被作为封面刊登，并且被评为该杂志当年最热门的十篇文章之一。曾多次应邀在全国蛋白组学、亚洲生物无机化学大会等做学术报告。主持国家科技部“973”项目子课题1项，国家自然科学基金1项，广东省自然科学基金2项，广州市科技计划1项，暨南大学引进人才启动经费1项。2011年年获得广州市首批珠江科技新星计划资助。学习经历：
2003-2006: 博士学位 香港大学
1999-2002: 硕士学位 南开大学/中科院微生物所
1995-1999: 学士学位 南开大学
工作经历：
2011-现在：暨南大学生命与健康工程研究院，研究员
2008-2011：暨南大学生命与健康工程研究院，副研究员
2007-2008：香港大学, 博士后
研究方向：
细菌感染及耐药相关机制的研究
细菌中的金属转运机制
主要著作：
1. Xuesong Sun, Jen-Fu Chiu, Qing-Yu He, “Fractionation of proteins by immobilized metal affinity chromatography”, Methods Mol. Biol. 2008, 424:205-12.(专著)
2. 《功能蛋白质研究》第四、五章，科学出版社，2012
主要论文：
1. Guo, Z., Han, J., Yang, X. Y., Cao, K., He, K., Du, G., Zeng, G., Zhang, L., Yu, G., Sun, Z., He, Q. Y.*, and Sun, X.* (2015) Proteomic analysis of the copper resistance of Streptococcus pneumoniae. Metallomics : integrated biometal science, 7(3):448-54
2. Yang, X. Y., Zhang, L., Liu, J., Li, N., Yu, G., Cao, K., Han, J., Zeng, G., Pan, Y., Sun, X., and He, Q. Y.* (2014) Proteomic analysis on the antibacterial activity of a Ru(II) complex against Streptococcus pneumoniae. J Proteomics, 115C, 107-116
3. Yang, X. Y., Sun, B., Zhang, L., Li, N., Han, J., Zhang, J., Sun, X.*, and He, Q. Y. * (2014) Chemical interference with iron transport systems to suppress bacterial growth of Streptococcus pneumoniae. PLoS One, 9, e105953
4. Wu, X., Xu, L., Gu, W., Xu, Q., He, Q. Y.*, Sun, X.*, and Zhang, G*. (2014) Iterative genome correction largely improves proteomic analysis of nonmodel organisms. J Proteome Res, 13, 2724-2734
5. Wang, N., Zhang, J., Zhang, L., Yang, X. Y., Li, N., Yu, G., Han, J., Cao, K., Guo, Z., Sun, X.*, and He, Q. Y.* (2014) Proteomic analysis of putative heme-binding proteins in Streptococcus pyogenes. Metallomics : integrated biometal science, 6, 1451-1459
6. Li, N., Yang, X. Y., Guo, Z., Zhang, J., Cao, K., Han, J., Zhang, G., Liu, L., Sun, X.*, and He, Q. Y.* (2014) Varied metal-binding properties of lipoprotein PsaA in Streptococcus pneumoniae. J Biol Inorg Chem, 19, 829-838
7. Ge, R., and Sun, X.* (2014) Iron acquisition and regulation systems in Streptococcus species. Metallomics : integrated biometal science, 6, 996-1003
8. Sun, X.*, Yu, G., Xu, Q., Li, N., Xiao, C., Yin, X., Cao, K., Han, J., and He, Q. Y.* (2013) Putative cobalt- and nickel-binding proteins and motifs in Streptococcus pneumoniae. Metallomics : integrated biometal science, 5, 928-935
9. Li, H., Li, N., Xu, Q., Xiao, C., Wang, H., Guo, Z., Zhang, J., Sun, X.*, and He, Q. Y.* (2013) Lipoprotein FtsB in Streptococcus pyogenes binds ferrichrome in two steps with residues Tyr137 and Trp204 as critical ligands. PLoS One, 8, e65682
10. Yang, X. Y., Lu, J., Sun, X.*, and He, Q. Y.* (2012) Application of subproteomics in the characterization of Gram-positive bacteria. J Proteomics, 75, 2803-2810
11. Sun, X.*, Yang, X. Y., Yin, X. F., Yu, G., Xiao, C. L., He, X., and He, Q. Y.* (2011) Proteomic analysis of membrane proteins from Streptococcus pneumoniae with multiple separation methods plus high accuracy mass spectrometry. OMICS, 15, 683-694
12. Sun, X., Xiao, C. L., Ge, R., Yin, X., Li, H., Li, N., Yang, X., Zhu, Y., He, X., and He, Q. Y.* (2011) Putative copper- and zinc-binding motifs in Streptococcus pneumoniae identified by immobilized metal affinity chromatography and mass spectrometry. Proteomics, 11, 3288-3298
13. Sun, X.*, Jia, H. L., Xiao, C. L., Yin, X. F., Yang, X. Y., Lu, J., He, X., Li, N., Li, H., and He, Q. Y.* (2011) Bacterial proteome of streptococcus pneumoniae through multidimensional separations coupled with LC-MS/MS. OMICS, 15, 477-482
14. Ge, R., Sun, X.#（共同第一）, Xiao, C., Yin, X., Shan, W., Chen, Z., and He, Q. Y.* (2011) Phosphoproteome analysis of the pathogenic bacterium Helicobacter pylori reveals over-representation of tyrosine phosphorylation and multiply phosphorylated proteins. Proteomics, 11, 1449-1461
15. Ge, R., Sun, X.#, and He, Q. Y.* (2011) Overview of the Metallometabolomic Methodology for Metal-Based Drug Metabolism. Curr Drug Metab,
16. Sun, X., Ge, R., Zhang, D., Sun, H., and He, Q. Y.* (2010) Iron-containing lipoprotein SiaA in SiaABC, the primary heme transporter of Streptococcus pyogenes. J Biol Inorg Chem, 15, 1265-1273
17. Sun, X., Ge, F., Xiao, C. L., Yin, X. F., Ge, R., Zhang, L. H., and He, Q. Y.* (2010) Phosphoproteomic analysis reveals the multiple roles of phosphorylation in pathogenic bacterium Streptococcus pneumoniae. J Proteome Res, 9, 275-282
18. Sun, X., Ge, R., Cai, Z., Sun, H., and He, Q. Y.* (2009) Iron depletion decreases proliferation and induces apoptosis in a human colonic adenocarcinoma cell line, Caco2. J Inorg Biochem, 103, 1074-1081
19. Sun, X., Baker, H. M., Ge, R., Sun, H., He, Q. Y.*, and Baker, E. N. * (2009) Crystal structure and metal binding properties of the lipoprotein MtsA, responsible for iron transport in Streptococcus pyogenes. Biochemistry, 48, 6184-6190
20. Sun, X., Ge, R., Chiu, J. F., Sun, H., and He, Q. Y.* (2008) Identification of Proteins Related to Nickel Homeostasis in Helicobater pylori by Immobilized Metal Affinity Chromatography and Two-Dimensional Gel Electrophoresis. Met Based Drugs, 2008, 289490
21. Sun, X., Ge, R., Chiu, J. F., Sun, H., and He, Q. Y.* (2008) Lipoprotein MtsA of MtsABC in Streptococcus pyogenes primarily binds ferrous ion with bicarbonate as a synergistic anion. FEBS Lett, 582, 1351-1354
22. Sun, X., Chiu, J. F., and He, Q. Y.* (2008) Fractionation of proteins by immobilized metal affinity chromatography. Methods Mol Biol, 424, 205-212
23. Sun, X., Chiu, J. F., and He, Q. Y.* (2005) Application of immobilized metal affinity chromatography in proteomics. Expert Rev Proteomics, 2, 649-657
24. Sun, X., Sun, H., Ge, R., Richter, M., Woodworth, R. C., Mason, A. B., and He, Q. Y.* (2004) The low pKa value of iron-binding ligand Tyr188 and its implication in iron release and anion binding of human transferrin. FEBS Lett, 573, 181-185
25. Zhou, Q., Qi, S., Sun, X., and Ge, R. (2014) The interaction of a histidine-rich protein hpn with the membrane mimics: implications for pathologic roles of Hpn in Helicobacter pylori. Helicobacter, 19, 129-135
26. Xiao, C. L., Chen, X. Z., Du, Y. L., Sun, X., Zhang, G., and He, Q. Y.* (2013) Binomial probability distribution model-based protein identification algorithm for tandem mass spectrometry utilizing peak intensity information. J Proteome Res, 12, 328-335
27. Ge, R., Sun, X., Wang, D., Zhou, Q., and Sun, H.* (2011) Histidine-rich protein Hpn from Helicobacter pylori forms amyloid-like fibrils in vitro and inhibits the proliferation of gastric epithelial AGS cells. Biochim Biophys Acta, 1813, 1422-1427
28. Ge, R., and Sun, X. (2011) The in vivo functions of a histidine-rich protein Hpn in Helicobacter pylori: linking gastric and Alzheimer’s diseases together? Med Hypotheses, 77, 788-790
29. Ge, R., and Sun, X. (2012) Iron trafficking system in Helicobacter pylori. Biometals, 25, 247-58.
30. Ge, R., Sun, X., Gu, Q., Watt, R. M., Tanner, J. A., Wong, B. C., Xia, H. H., Huang, J. D., He, Q. Y.*, and Sun, H. (2007) A proteomic approach for the identification of bismuth-binding proteins in Helicobacter pylori. J Biol Inorg Chem, 12, 831-842
31. Ge, R., Zhang, Y., Sun, X., Watt, R. M., He, Q. Y., Huang, J. D., Wilcox, D. E., and Sun, H.* (2006) Thermodynamic and kinetic aspects of metal binding to the histidine-rich protein, Hpn. J Am Chem Soc, 128, 11330-11331
32. Ge, R., Watt, R. M., Sun, X., Tanner, J. A., He, Q. Y.*, Huang, J. D.*, and Sun, H.* (2006) Expression and characterization of a histidine-rich protein, Hpn: potential for Ni2+ storage in Helicobacter pylori. Biochem J, 393, 285-293
33. Yang, P. H., Sun, X., Chiu, J. F., Sun, H., and He, Q. Y.* (2005) Transferrin-mediated gold nanoparticle cellular uptake. Bioconjug Chem, 16, 494-496
34. Ge, R., Lin, H., Xu, X., Sun, X., Zhu, S., Ji, B., Li, F., and Wu, H. (2004) Catalysis of phosphoryl transfer from adenosine-5’-triphosphate (ATP) by trinuclear "chelate" complexes. J Inorg Biochem, 98, 917-924
35. Xue, Y., Sun, X., Zhou, P., Liu, R., Liang, F., and Ma, Y. * (2003) Gordonia paraffinivorans sp. nov., a hydrocarbon-degrading actinomycete isolated from an oil-producing well. Int J Syst Evol Microbiol, 53, 1643-1646
承担课题：
1. 结肠癌及其相关巨噬细胞的分泌蛋白质与肿瘤发展的相关研究（2011CB910701）。国家科技部“973” 子课题 ，36万，2011.1-2012-12。
2.肺炎链球菌中锰转运蛋白PsaA锰离子结合特性的研究（31000373）。国家自然基金-青年基金， 20万， 2011.1-2013.12。
3. 锌蛋白介导的肺炎链球菌锌离子摄取机制的研究（S2012010008685）。 广东省自然基金，5万，2012-2014.9。
4. 基于脂蛋白PsaA的肺炎链球菌锰运输机制的研究（10451063201005247）。广东省自然基金，3 万，2010.10-2012.9。
5. 肺炎链球菌锰摄取机制的研究（33111013）。广州市珠江科技新星计划，30万，2012.1-2013.12。
6. 肺炎链球菌锰转运机制的研究（21611201）。暨南大学创新与培育项目-杰出人才，60万，2011.1-2013.12。
7. 肺炎链球菌锰转运机制的研究（21609301）。暨南大学创新与培育项目-青年项目，2.5 万，2010.1-2010.12。
8. 肺炎链球菌锰转运机制的研究（51208047）。暨南大学引进人才启动基金，4 万，2008.5-2010.5。
9. 化脓链球菌中转铁蛋白MtsA和HtsA金属结合特性的研究 。211工程三期预研项目，4万，2008.12-2009.12。
荣誉与奖励：
1. 广东省“千百十”工程校级培养对象，2010。
2. 广州市珠江科技新星，2011。
