宋文俊(研究员)的个人简介
宋文俊,男,暨南大学生命科学技术学院副研究员。
基本内容
学习经历:
2001u20132005新加坡国立大学,生命科学系,博士
1993u20131997华东理工大学,生物化学专业,本科
工作经历:
2015年u2013至今 暨南大学,生命科学技术学院,副教授
2011年u20132014年 香港大学,微生物系,研究员 (Research Officer)
2006年u20132010年 香港大学,微生物系,博士后 (Post-doc Research Fellow)
1997年u20132000年 中国科学院上海生化所,酶工程组,研究实习员。
研究方向:
1. 流感病毒致病分子机制研究;
2. 流感及呼吸道病毒临床快速诊断技术方法研究;
3. 流感及呼吸道相关病毒临床免疫治疗技术平台研发;
4. 新型安全高效流感疫苗研发。
主要论文:
1. Song, W.*, P. Wang*, B. W. Mok, S. Y. Lau, X. Huang , W. L. Wu, M. Zheng, X. Wen , S.Yang, Y. Chen, L. Li, K. Y. Yuen, and H. Chen. 2014. The K526R substitution in viral 1 protein PB2 enhances the effects of E627K on influenza replication. Nature Communications 5:5509. *Equal contribution.
2. To, K. K., W. Song, S. Y. Lau, T. L. Que, D. C. Lung, I. F. Hung, H. Chen, and K. Y. Yuen. 2014. Unique reassortant of influenza A(H7N9) virus associated with severe disease emerging in Hong Kong. The Journal of infection 69:60-68.
3. Wen, X., X. Huang, B. W. Mok, Y. Chen, M. Zheng, S. Y. Lau, P. Wang, W. Song, D. Y. Jin, K. Y. Yuen, and H. Chen. 2014. NF90 exerts antiviral activity through regulation of PKR phosphorylation and stress granules in infected cells. Journal of immunology 192:3753-3764.
4. Chen, Y., W. Liang, S. Yang, N. Wu, H. Gao, J. Sheng, H. Yao, J. Wo, Q. Fang, D. Cui, Y. Li, X. Yao, Y. Zhang, H. Wu, S. Zheng, H. Diao, S. Xia, Y. Zhang, K. H. Chan, H. W. Tsoi, J. L. Teng, W. Song, P. Wang, S. Y. Lau, M. Zheng, J. F. Chan, K. K. To, H. Chen, L. Li, and K. Y. Yuen. 2013. Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome. Lancet 381:1916-1925.
5. Mok, B. W., W. Song, P. Wang, H. Tai, Y. Chen, M. Zheng, X. Wen, S. Y. Lau, W. L. Wu, K. Matsumoto, K. Y. Yuen, and H. Chen. 2012. The NS1 protein of influenza A virus interacts with cellular processing bodies and stress granules through RNA-associated protein 55 (RAP55) during virus infection. Journal of virology 86:12695-12707.
6. Wu, W. L., S. Y. Lau, Y. Chen, G. Wang, B. W. Mok, X. Wen, P. Wang, W. Song, T. Lin, K. H. Chan, K. Y. Yuen, and H. Chen. 2012. The 2008-2009 H1N1 influenza virus exhibits reduced susceptibility to antibody inhibition: Implications for the prevalence of oseltamivir resistant variant viruses. Antiviral research 93:144-153.
7. Zhang, J., Z. Zhang, X. Fan, Y. Liu, J. Wang, Z. Zheng, R. Chen, P. Wang, W. Song, H. Chen, and Y. Guan. 2010. 2009 pandemic H1N1 influenza virus replicates in human lung tissues. J Infect Dis 201:1522-1526.
8. Lin, S., N. Liu, Z. Yang, W. Song, P. Wang, H. Chen, M. Lucio, P. Schmitt-Kopplin, G. Chen, and Z. Cai. 2010. GC/MS-based metabolomics reveals fatty acid biosynthesis and cholesterol metabolism in cell lines infected with influenza A virus. Talanta 83:262-268.
9. Liu, N., W. Song, P. Wang, K. C. Lee, Z. Cai, and H. Chen. 2010. Identification of unusual truncated forms of nucleocapsid protein in MDCK cells infected by Avian influenza virus (H9N2). Proteomics 10:1875-1879.
10. Lin, T., G. Wang, A. Li, Q. Zhang, C. Wu, R. Zhang, Q. Cai, W. Song, and K. Y. Yuen. 2009. The hemagglutinin structure of an avian H1N1 influenza A virus. Virology 392:73-81.
11. Liu, N., W. Song, K. C. Lee, P. Wang, H. Chen, and Z. Cai. 2009. Identification of amino acid substitutions in avian influenza virus (H5N1) matrix protein 1 by using nanoelectrospray MS and MS/MS. J Am Soc Mass Spectrom 20:312-320.
12. Wang, P.*, W. Song*, B. W. Mok, P. Zhao, K. Qin, A. Lai, G. J. Smith, J. Zhang, T. Lin, Y. Guan, and H. Chen. 2009. Nuclear factor 90 negatively regulates influenza virus replication by interacting with viral nucleoprotein. Journal of virology 83:7850-7861.
*Equal contribution.
13. Song, W., Q. Lin, S. B. Joshi, T. K. Lim, C. L. Hew. 2006. Proteomic studies of the Singapore grouper iridovirus. Molecular & Cellular Proteomics : MCP 5: 256-64.
14. Song, W. J., Q. W. Qin, J. Qiu, C. H. Huang, F. Wang, C. L. Hew. 2004. Functional genomics analysis of Singapore grouper iridovirus: complete sequence determination and proteomic analysis. Journal of Virology 78: 12576-90.