孙宝林(中国科大教授)

时间:2023-12-04 19:25:48编辑:小蔡

孙宝林(中国科大教授)的个人简介

孙宝林,男,博士,中国科学技术大学教授、博士生导师。

人物经历

1986年牡丹江师范学院学士;

1989年中科院遗传所硕士;

1999年密歇根州立大学博士。

研究方向

1、细菌病原体毒力基因的表达调控

2、耐药发生与转移的调控机制

3、病原菌与宿主互作机制

科研项目

1. 中国科学院“百人计划”专项,2004.01u20132007.12,资助金额:270万。

2. 国家“十一五”科技重大专项“艾滋病和病毒性肝炎等重大传染病防治”子课题“结核病靶标研究”,2008.10u20132011.05,资助金额:315万。

3. 中国科学院知识创新工程“结核分枝杆菌致病机制、快速诊断和新型药物研究”,2009.6u20132011.05,资助金额:60万。

4. 国家自然科学基金“金黄色葡萄球菌非编码小RNA的功能解析”,2010.01u20132012.12,资助金额:40万。

5. 国家自然科学基金“金黄色葡萄球菌KdpDE二元信号转导系统对致病性的调控研究”,2011.01u20132013.12,资助金额:34万。

论文专著

Xiong, M., Y. Bao, X. Yang, Y. Wang, B. Sun, and J. Wang (2012). Lipase-sensitive polymeric triple-layered nanogel for "on-demand" drug delivery.J. Am. Chem. Soc. 134:4355-4362.

Xue, T., Y. You, F. Shang, and B. Sun (2012). Rot and Agr system modulate fibrinogen-binding ability mainly by regulatingclfBexpression inStaphylococcus aureusNCTC8325.Med. Microbiol. Immunol.201:81-92.

Xue, T., Y. You, D. Hong, H. Sun, and B. Sun (2011). TheStaphylococcus aureusKdpDE two-component system couples extracellular K sensing and Agr signaling to infection programming.Infect. Immun.79:2154-2167.

Zhao, L., T. Xue, F. Shang, H. Sun, and B. Sun (2010).Staphylococcus aureusAI-2 quorum sensing associates with the KdpDE two-component system to regulate capsular polysaccharide synthesis and virulence.Infect. Immun.78:3506-3515.

Tao, L., X. Wu, and B. Sun (2010). Alternative sigma factor σ modulates prophage integration and excision inStaphylococcus aureus.PLoS Pathog.6:e1000888.

Shang, F., T. Xue, H. Sun, L. Xing, S. Zhang, Z. Yang, L. Zhang, and B. Sun (2009). TheStaphylococcus aureusGGDEF domain-containing protein, GdpS, influences protein A gene expression in a cyclic diguanylic acid-independent manner.Infect. Immun.77:2849-2856.

Huang, J., B. Sun, and X. Zhang (2010).Shewanella xiamenensissp. nov., isolated from coastal sea sediment.Int. J. Syst. Evol. Microbiol. 60:1585-1589.

Huang, J., B. Sun, and X. Zhang (2010). Electricity generation at high ionic strength in microbial fuel cell by a newly isolatedShewanella marisflaviEP1.Appl. Microbiol. Biotechnol. 85:1141-1149.

Xue, T., L. Zhao, H. Sun, X. Zhou, and B. Sun (2009). LsrR binding-site recognition and regulatory characteristics inEscherichia coliAI-2 quorum sensing.Cell Res.19:1258-1268.

Wu, C. and B. Sun (2009). Identification of novel esterase from metagenomic library of Yangtze River.J. Microbiol. Biotechnol.19:187-193.

Chu, X., H. He, C. Guo, and B. Sun (2008). Identification of two novel esterases from a marine metagenomic library derived from South China Sea.Appl. Microbiol. Biotechnol.80:615-625.

Zhou, X., X. Meng, and B. Sun (2008). An EAL domain protein and cyclic AMP contribute to the interaction between the two quorum sensing systems inEscherichia coli.Cell Res.18:937-948.

Ju, X., L. Zhao, and B. Sun (2007). Nitrogen fixation by reductively dechlorinating bacteria.Environ. Microbiol.9:1078-1083.

Sun, B., B. M. Griffin, H. L. Ayala-del-Río, S. A. Hashsham, and J. M. Tiedje (2002). Microbial dehalorespiration with 1,1,1-trichloroethane.Science298:1023-1025.

Sun, B., J. R. Cole, and J. M. Tiedje (2001).Desulfomonile limimarissp. nov., an anaerobic dehalogenating bacterium from marine sediments.Int. J. Syst. Evol. Microbiol.51:365-371.

Sun, B., J. R. Cole, R. A. Sanford, and J. M. Tiedje (2000). Isolation and characterization ofDesulfovibrio dechloracetivoranssp. nov., a marine dechlorinating bacterium growing by coupling the oxidation of acetate to the reductive dechlorination of 2-chlorophenol.Appl. Environ. Microbiol.66:2408-2413.

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